Oracle 7 application running against Oracle 8i (HP-UX)

I am maintaining an application that has been built against Oracle 7 on an HP-UX machine. I have customers that have been able to run this application against Oracle 8i, but I have been unable to do it. My application is unable to connect to the Oracle Database. I can connect to oracle using sqlplus while logged in as the Unix oracle user using the as the oracle user that my application uses. But I can't connect using the Unix user that my application runs under. Any ideas? Thanks in advance,
SkiDad . . .

Particulars:
I did the installation of Oracle myself, hence there may be configuration errors.
Oracle 8i (8.1.6)
HP-UX 11.0 (With patches required by Oracle) Running a single instance, with a single small data base. SID: "milo"
dbname "test.milo"
My application writes the following error message. I assume that the text of this message is from Oracle:

   Wed Oct 18 10:17:43 2000

     r21_initialize (E-Code):-6108 ORA-06108: Unable to open message
     file (SQL-02113).
     r21_initialize (E-Text):

I can connect to oracle using sqlplus when logged in as the oracle user:

-> sqlplus

    SQL*Plus: Release 8.1.6.0.0 - Production on Wed Oct 18 10:10:58 2000

    (c) Copyright 1999 Oracle Corporation. All rights reserved.

    Enter user-name: xxx
    Enter password:

    Connected to:
    Oracle8i Release 8.1.6.0.0 - Production     JServer Release 8.1.6.0.0 - Production

    SQL> quit
    Disconnected from Oracle8i Release 8.1.6.0.0 - Production     JServer Release 8.1.6.0.0 - Production
->

But I can't connect to oracle when working as the user under which the application runs:

-> sqlplus

    SQL*Plus: Release 8.1.6.0.0 - Production on Wed Oct 18 10:22:09 2000

    (c) Copyright 1999 Oracle Corporation. All rights reserved.

    Enter user-name: xxx
    Enter password:
    ERROR:
    ORA-06401: NETCMN: invalid driver designator

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Before you buy. Received on Wed Oct 18 2000 - 13:02:29 CDT