Can I rerun catalog.sql while db is open?

I'm getting export errors when I try to do a consistent export, I think that the first thing to do is re-run the catalog, catproc and catexp scripts. I'm doing this on a test box but there are some folks using it. Other than taking a performance hit is there any problem doing this while the db is open or should I wait. I have read a bunch of metalink articles about the problem I'm experiencing an none of them say there is any problem with this.

Thanks,
Ethan

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